How do you administer IV midazolam?

The IV induction dose of midazolam should be given slowly in increments. Each increment of not more than 5mg should be injected over 20 to 30 seconds allowing 2 minutes between successive increments. In premedicated adults below the age of 60 years, an IV dose of 0.15 to 0.2mg/kg will usually suffice.

How long does midazolam take to wear off?

Effects last from one to six hours. Midazolam has an amnesia effect, which lasts anywhere from 20 minutes to an hour. Most of a dose of midazolam is eliminated via urine, although some are eliminated via feces as well. For most adults, an entire dose of midazolam is eliminated within a day.

What difficulties might occur when administering buccal midazolam?

What are the side effects? Breathing difficulties – your child is unlikely to have breathing difficulties if midazolam is given at the correct dosage. If breathing difficulties do develop, seek medical assistance. Restlessness, agitation and disorientation – these can occur but are usually rare.

What are the indications for use of midazolam?

Midazolam is used before surgery or a procedure. It helps to cause drowsiness, decrease anxiety, and to decrease your memory of the surgery or procedure. This medication may also be used to help with anesthesia or to sedate people who need a tube or machine to help with breathing.

How do you dilute IV midazolam?

For continuous infusion, midazolam 5 mg/mL formulation is recommended diluted to a concentration of 0.5 mg/mL with 0.9% sodium chloride or 5% dextrose in water.

What’s the difference between midazolam and triazole?

Midazolam has imidazole ring instead of triazole ring and a fluorine group on phenyl ring. Here again the imidazole is given numbering and sides of benzodiazepine are labelled with letters a,b,c. It can be noticed that 1st and 5th atoms of imidazole are fused with “a” side of benzodiazepine.

What kind of substitution reaction does imidazole undergo?

Imidazole is a base and an excellent nucleophile. It easily undergoes electrophilic (alkylating, acylating) substitution reactions at the –NH nitrogen. However, the C 4 and C 5 atoms of imidazole are also susceptible to electrophilic attacks.

How are the triazole rings in alprazolam numbered?

As alprazolam is a triazolo benzodiazepine, let’s give numbering to triazole ring and labelling to bonds in benzodiazepine. In alprazolam, the 3rd and 4th atoms of 1,2-4-triazole ring are fused with “a” bond on benzodiazepine. Therefore name of the fused ring system can be written as

What kind of pH does midazolam have?

Midazolam exists in a pH equilibrium between closed and open ring structures.11The benzodiazepine ring of midazolam opens at lower pH.