What does a high CD57 mean?
It is generally believed that the lower the amount of CD57 natural killer cells in the body, the more chronic or progressive Lyme disease is, and the higher the amount, the closer a person is to remission.
Do T cells express CD56?
CD56 is a homologue of neural cell adhesion molecule present on most natural killer (NK) cells and also a small subpopulation of T cells. T cells expressing CD56 have been variously referred to as CD3+ CD56+ cells,3 NK-like T cells4 and cytokine-induced killer cells.
What do low CD57 NK cells mean?
The CD57 is expressed on both natural killer (NK) cells and T lymphocytes. The CD57 test measures CD57 positive NK cells only. The test is performed on EDTA whole blood. In patients with low CD 57 counts, Lyme disease and Chlamydophila pneumoniae infections should be included in differential diagnosis.
What causes high CD57 count?
Chronic viral infections such as HCMV (104), human immunodeficiency virus (HIV) (105), hepatitis C virus (106), and Epstein–Barr virus (EBV) (107) infections offer some of the clearest examples of expansion of CD57+CD8+ T cells, presumably as a result of persistent antigenic stimulation, and increased proportions of …
What should your CD57 be?
The standard normal range for the absolute CD57 NK count is 60 to 360 cells per microliter of blood. This wide range was established based upon test results of hundreds of healthy patients.
Do NKT cells express CD8?
An examination of NKT cell subsets in CD1d−/− mice revealed the CD1d-independent NKT cell subset; approximately 50% of the cells therein express CD816. This CD8-expressing CD1d-independent NKT cell subset has been referred to as “CD8+NKT cells” in some previous studies17,18,19.
What are CD 57 cells?
CD57 is a Marker of NK Cell Differentiation CD57 was subsequently identified on CD8+ T cells (5–7) as well as cells of neural crest origin (1, 8–13). Indeed, it was the neuroscience community that ultimately defined CD57 as a terminally sulfated carbohydrate epitope (glucuronic acid 3-sulfate) (14–16).
What is CD57 test used for?
CD57 Blood Test for Lyme Disease The Lyme Disease CD57 HNK1 test is used to aid in the diagnosis of Lyme Disease as well as to monitor treatment. Lyme Disease tends to suppress a person’s immune system and many people with Lyme have shown a low count for the CD57 Lymphocyte.