What is a Nonseminomatous germ cell tumor?
Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. They originate from cells that were meant to form sex cells (i.e., sperm or eggs).
What tumor marker is Nonseminomatous testicular cancer?
Alpha-fetoprotein Therefore any patient with an elevated AFP must have a nonseminomatous component of testis cancer. AFP can be elevated in patients with a number of other malignancies, including with hepatocellular (liver) carcinoma, cancer of the stomach, pancreas, biliary tract and lung.
What is the difference between seminoma and Nonseminomatous?
Seminomas are very sensitive to radiation therapy. Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to these different cell types: Choriocarcinoma (rare)
What is the most common germ cell tumor of the testis?
Two of the most common germ cell tumors are seminoma and nonseminoma. Seminomas make up about half of all germ cell tumors. They usually grow slowly.
What does Nonseminomatous mean?
(NON-seh-mih-NOH-muh) A type of cancer that begins in cells that form sperm or eggs. There are several types of nonseminoma tumors, including embryonal carcinoma, malignant teratoma, choriocarcinoma, and yolk sac tumor. These tumors are usually made up of more than one type of cancer cell.
What is non-Seminomatous germ cell?
The group of non-seminomatous germ cell tumors includes embryonal carcinoma, yolk sac tumor, choriocarcinoma and teratoma. All entities can occur rarely in pure form or much more commonly in mixed germ cell tumors consisting of more than one histological type.
Which of the following tumor markers is elevated in testicular cancer?
Many testicular cancers make high levels of certain proteins called tumor markers, such as alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). When these tumor markers are in the blood, it suggests that there’s a testicular tumor.
Which of the following is a tumor marker of Nonseminomatous germ cell tumors?
Serum hCG and AFP are the most important tumor markers. AFP levels are elevated in 50-70% of patients with NSGTs, and hCG levels are elevated in 40%-60%. AFP has a half-life of 5-7 days, and hCG has a half-life of 24-48 hours.
What is the most common type of testicular tumor?
The most common type of testis cancer is a germ cell tumor. There are two main types of GCT: seminoma and nonseminomatous germ cell tumors (NSGCT). Both seminoma and NSGCT occur at about the same rate, and men can have seminoma, NSGCT or a combination of both.
What is germ cell in testis?
More than 90% of cancers of the testicle start in cells known as germ cells. These are the cells that make sperm. The main types of germ cell tumors (GCTs) in the testicles are seminomas and non-seminomas. These types occur about equally.
What is the meaning of seminoma?
(SEH-mih-NOH-muh) A type of cancer that begins in germ cells in males. Germ cells are cells that form sperm in males or eggs in females. Seminomas occur most often in the testicle, but they may also occur in other areas of the body, such as the brain, chest, or abdomen.
What is germ cell cancer?
Germ cell cancer is a condition that affects the cells that form a man’s sperm or a woman’s eggs.
What is a mixed germ cell tumor?
Mixed Germ Cell Tumor of the Testis is a type of testicular cancer affecting the germ cells. Germ cells are precursors to sperm cells that will eventually transform into sperms. The testes are the male reproductive organs, equivalent to the ovaries in women.
What are neoplasia, tumors and cancer?
Neoplasia is the abnormal growth and proliferation of abnormal cells or abnormal amounts of cells due to a benign or malignant process. There can be benign tumors, or neoplasms, and malignant ones. Remember that it’s the malignant tumors, or cancer, that can metastasize, which is when cancer spreads around the body.