What is Gemigliptin used for?

Gemigliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Gemigliptin is under investigation in Type 2 Diabetes Mellitus. Gemigliptin has been investigated for the treatment of Cancer and Cisplatin Adverse Reaction.

What is Gemigliptin Zemiglo?

Gemigliptin tablet 50 mg is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated in adults aged 18-75 years with type 2 diabetes mellitus. Gemigliptin tablet 50 mg can be administered: As monotherapy: as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus.

What are the names of DPP-4 inhibitors?

Medicines in the DPP-4 inhibitor class include sitagliptin, saxagliptin, linagliptin, and alogliptin.

How do ddp4 inhibitors work?

DPP-4 inhibitors work by blocking the action of DPP-4, an enzyme which destroys the hormone incretin. Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed.

What are the side effects of alogliptin?

The most common side effects of alogliptin are headaches, indigestion, diarrhoea and skin rashes. This medicine does not usually make you put on weight. Alogliptin is also called by the brand name Vipidia.

What are the common side effects of gliclazide?

Common side effects

stomach ache or indigestion.
feeling sick (nausea)
being sick (vomiting) or diarrhoea.
constipation.

Which is the best DPP-4 inhibitor?

Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes.

What is the brand name for sitagliptin?

Sitagliptin is a prescription drug. It comes as an oral tablet. Sitagliptin oral tablet is available as the brand-name drug Januvia.

How do GLP-1 receptor agonists work?

The GLP-1RAs have been shown to significantly improve glycemic parameters and reduce body weight. These agents work by activating GLP-1 receptors in the pancreas, which leads to enhanced insulin release and reduced glucagon release-responses that are both glucose-dependent-with a consequent low risk for hypoglycemia.

Who should not take alogliptin?

Alogliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).

What is the best time of day to take alogliptin?

You can generally take alogliptin at a time of day to suit you, but it is best to take your doses at the same time of day each day. Swallow the tablet with a drink of water – you can take it either with or without food.

How is gemigliptin used in type 2 diabetes?

Are there any side effects to taking gemigliptin?

Some of the side effects of taking Gemigliptin are Nasopharyngitis, headaches, hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea. If you encounter a severe allergic reaction or joint pain, alert your doctor immediately.

What kind of drug is gemigliptin DPP-4 inhibitor?

Description: Gemigliptin, also known as LC15-0444, is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor was approved in South Korea as an oral anti-hyperglycemic agent (anti-diabetic drug). Gemigliptin dose-dependently inhibited methylglyoxal-modified AGE-bovine serum albumin (BSA) formation (IC50=11.69 mM).

When was gemigliptin approved for use in Korea?

The NDA for gemigliptin was submitted to the Korea Food & Drug Administration (KFDA) in July 2011, and it was approved in June 2012. By the end of 2012, gemigliptin will be marketed in Korea as Zemiglo which is the fifth new DPP-4 inhibitor diabetes treatment in the world.