What is immunofixation electrophoresis?

Immunofixation electrophoresis or immunosubtraction capillary electrophoresis identifies the type of immunoglobulin protein(s) present as monoclonal bands on a protein electrophoresis pattern. Typically, this testing determines the presence and type of monoclonal proteins (e.g., IgG kappa).

What does a positive immunofixation blood test mean?

Positive results from the test indicate the presence of abnormal Ig. This may suggest the existence of an underlying health condition, such as: an immune system disorder. multiple myeloma. Waldenstrom’s macroglobulinemia.

What is immunofixation test used for?

The immunofixation blood test is used to identify proteins called immunoglobulins in blood. Too much of the same immunoglobulin is usually due to different types of blood cancer. Immunoglobulins are antibodies that help your body fight infection.

What is Immunofix Phoresis serum?

An immunofixation blood test, also known as protein electrophoresis, measures certain proteins in the blood. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. There are two main types of proteins in the blood: albumin and globulin.

What does an electrophoresis blood test show?

Protein electrophoresis is a test that measures specific proteins in the blood. The test separates proteins in the blood based on their electrical charge. The protein electrophoresis test is often used to find abnormal substances called M proteins.

What does a negative Immunofixation blood test mean?

A normal (negative) result means that the blood sample had normal types of immunoglobulins. The level of one immunoglobulin was not higher than any other.

What is Immunofixation result?

Immunofixation can either reveal a normal pattern or identify a monoclonal protein or a polyclonal immunoglobulin pattern. A normal result includes a darker immunoglobulin G (IgG) lane, a lighter immunoglobulin A (IgA), an absent immunoglobulin M (IgM), and a denser kappa compared to lambda lane, with ratio of 2:1.

What does it mean when your gamma globulin is high?

Increased gamma globulin proteins may indicate: Blood cancers, including multiple myeloma, Waldenström macroglobulinemia, lymphomas, and chronic lymphocytic leukemias. Chronic inflammatory disease (for example, rheumatoid arthritis) Acute infection.

What does low gamma globulin indicate?

Low levels of gamma globulins suggest the under-production of antibodies as found in certain genetic diseases (bubble boy agammaglobulinemia) and leukemia. Other tests can more accurately identify which fraction or sub-component of gamma globulins may be abnormal (protein immunofixation, free kappa or lambda chains).

What does hemoglobin electrophoresis test for?

Hemoglobin electrophoresis measures hemoglobin levels and looks for abnormal types of hemoglobin. It’s most often used to help diagnose anemia, sickle cell disease, and other hemoglobin disorders.

What is electrophoresis used for?

Electrophoresis is a laboratory technique used to separate DNA, RNA, or protein molecules based on their size and electrical charge. An electric current is used to move molecules to be separated through a gel.