What medicine cancels out the Depo shot?

Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include:

barbiturates.
bosentan.
carbamazepine.
felbamate.
griseofulvin.
oxcarbazepine.
phenytoin.
rifampin.

Does ibuprofen cancel out the Depo shot?

No interactions were found between Depo-Provera and ibuprofen. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What supplements should I take while on Depo-Provera?

People who use the shot may have a temporary loss of bone density but the bone loss is largely reversible once the method is stopped. Calcium (1200 mg/day) and vitamin D supplements are recommended while using the shot.

What can stop Depo from working?

Spotting and continuous bleeding are the main reasons people stop taking Depo-Provera. People who use Depo-Provera are more likely to stay on it if they are counseled about this potential side effect before receiving their first injection.

What can cause Depo-Provera to fail?

The shot. The shot contains a progestin (a synthetic form of progesterone) that lasts three months (1). It can fail if a person doesn’t receive their next dose in time, or if it is given incorrectly (10).

What can make the Depo shot ineffective?

Examples include griseofulvin, modafinil, rifamycins (such as rifampin, rifabutin), St. John’s wort, drugs used to treat seizures (such as barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate), HIV drugs (such as nelfinavir, nevirapine, ritonavir), among others.

Can ibuprofen interfere with birth control?

REGULAR DAILY USE OF NSAIDs such as ibuprofen (Advil and Motrin) and naproxen (Aleve) and some other medications are not safe to take with birth control pills containing Drospirenone.

How can I reduce the side effects of Depo-Provera?

Certain medication may help to stop the bleeding and spotting side effects of the birth control shot. However, there is no evidence to support routine use of this type of treatment. The first option your doctor might suggest is a nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen (Advil).