What are newer macrolides?

Azithromycin and clarithromycin are two relatively new macrolide antimicrobial agents. Although azithromycin and clarithromycin are structural analogues of erythromycin, they offer distinct advantages in comparison.

Which is the best macrolide?

Erythromycin, azithromycin and clarithromycin are equally effective against most gram-positive organisms. However, clarithromycin and azithromycin have much better activity against Haemophilus influenza and Moraxella catarrhalis. Thus, these 2 drugs are better choices for the treatment of community-acquired pneumonia.

What antibiotics are considered macrolides?

Macrolides are a class of antibiotic that includes erythromycin, roxithromycin, azithromycin and clarithromycin.

What are extended macrolides?

Aka: Extended Spectrum Macrolide, Azithromycin, Zithromax, Clarithromycin, Biaxin, Telithromycin, Ketek.

Which is better azithromycin or clarithromycin?

Overall mortality rates were significantly lower in patients treated with azithromycin (3.7 percent) than in those treated with clarithromycin (7.3 percent). The incidence of bacteremia, which was associated with a higher risk of mortality, was similar in the two macrolide treatment groups.

What is the best antibiotic for community acquired pneumonia?

The initial treatment of CAP is empiric, and macrolides or doxycycline (Vibramycin) should be used in most patients.

Why do macrolides cause QT prolongation?

This is not surprising, as structurally similar macrolides have also been shown to cause QT interval prolongation. The mechanism by which clarithromycin induces QT prolongation is thought to be through the inhibition of the rapidly activating delayed rectifier potassium current (IKr) in cardiac myocytes.

How are macrolides used to treat bacterial infections?

Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome.

Which is the best name for a macrolide?

List of Macrolides: Drug Name Avg. Rating Reviews Zithromax ( Pro) Generic name: azithromy 7.3 126 reviews Biaxin ( Pro) Generic name: clarithromyc 6.5 87 reviews Azithromycin Dose Pack Generic name: azi 6.7 64 reviews Dificid ( Pro) Generic name: fidaxomicin 7.9 10 reviews

What are the medical conditions associated with macrolides?

Medical conditions associated with macrolides: Babesiosis. Bacterial Endocarditis Prevention. Bacterial Infection. Bartonellosis. Bowel Preparation. Bronchitis. Bullous Pemphigoid.

How are macrolides used to inhibit protein synthesis?

Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome.