What is Glucantime used for?

Glucantime is an effective drug for the treatment of cutaneous leishmaniasis in central Iran. However, because cutaneous leishmaniasis heals spontaneously and to prevent the acquisition of resistance, the indications for treatment in each region should be defined carefully.

Is Glucantime toxic?

N-methylglucamine antimoniate (Glucantime) is used to treat visceral leishmaniasis but may give rise to serious and sometimes lethal complications: cardiac, hepatic, renal and haematological disease.

What is Glucantime injection?

Glucantime is the most common stibied derivative used to treat cutaneous leishmaniasis (CL) in Tunisia; however adverse effects have been reported.

How do you give sodium stibogluconate?

Sodium stibogluconate is usually administered by intravenous or intramuscular injection daily at a dose of 20 mg/kg/day (maximum 850 mg) for 21–28 days. Intralesional injections may be used for a single lesion or a few small lesions of cutaneous leishmaniasis.

What is the mechanism of action of sodium stibogluconate?

Mechanism of action and use Sodium stibogluconate is an organic antimony derivative. Its mechanism is unclear but it may act by binding to thiol groups in the parasite and inhibiting the formation of high-energy phosphates (ATP and guanosine triphosphate [GTP]). It is used to treat visceral leishmaniasis.

What is Antimonial compound?

Pentavalent antimonials (also abbreviated pentavalent Sb or SbV) are a group of compounds used for the treatment of leishmaniasis. They are also called pentavalent antimony compounds.

What are pentavalent drugs?

The pentavalent antimonials, meglumine antimoniate (Glucantime) and sodium stibogluconate (Pentostam), have been used since the 1930s and are considered the front-line drugs of choice for all the clinical forms of leishmaniasis, although their mechanisms of action have remained essentially unknown.