How is tenofovir Alafenamide eliminated?

How is tenofovir Alafenamide eliminated?

Unlike TFV, TAF is minimally eliminated in urine. The pharmacokinetics (PK) of TAF and TFV in HIV-uninfected subjects with severe renal impairment and matched healthy controls were evaluated.

What is the difference between tenofovir Alafenamide and tenofovir disoproxil fumarate?

Compared with tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF) results in a 91% reduction in plasma tenofovir (TFV) exposure and has demonstrated less impact on surrogate markers of renal and bone health in multiple populations, but the clinical impact of these differences has not been fully …

What is tenofovir Alafenamide used for?

Tenofovir alafenamide is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.

Is tenofovir Alafenamide safe in pregnancy?

Introduction: Tenofovir alafenamide (TAF)-containing fixed-dose drug combinations (FDCs) are increasingly being used in managing pregnant women living with HIV. However, TAF is not currently recommended during pregnancy due to limited pharmacokinetic and safety data.

When did tenofovir Alafenamide come out?

The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015.

Why is TAF less toxic than TDF?

TAF is a prodrug that is absorbed more quickly than TDF and produces higher levels of the active drug, known as tenofovir diphosphate, in cells. This means it can be given in smaller doses, leading to lower drug levels in the blood and less exposure for the kidneys, bones and other organs.

What are the two types of tenofovir?

Two forms of the drug are available: the older tenofovir disoproxil fumarate and the newer tenofovir alafenamide. TAF is a prodrug that is absorbed more quickly than TDF and produces higher levels of the active drug, known as tenofovir diphosphate, in cells.

What is the brand name for tenofovir Alafenamide?

The emtricitabine/tenofovir alafenamide FDC tablet (brand name: Descovy) is also approved for HIV pre-exposure prophylaxis (PrEP).

When should I take tenofovir Alafenamide?

Take this medication by mouth with food as directed by your doctor, usually once daily. If you are on dialysis, on your dialysis days, take your daily dose of this medication following dialysis.

Is Vemlidy safe during pregnancy?

Vemlidy Prevents Transmission of Hepatitis B From Mother to Infant. Two different studies found that Vemlidy was safe and effective for pregnant women and their infants.