Is Palmoplantar Keratoderma a rare disease?

Punctate palmoplantar keratoderma type I is a rare condition that affects the skin. It is a sub-type of punctate palmoplantar keratoderma. Signs and symptoms typically begin in early adolescence or later and include hard, round bumps of thickened skin on the palms of the hands and soles of the feet.

Is keratosis Punctata painful?

The lesions are aggravated by friction, and, occasionally, they may be painful. Histologic features include hyperkeratosis and parakeratosis. Treatment may include keratolytics and topical retinoids. Synonyms include punctate PPK type II, porokeratotic-type PPK, or spiny keratoderma.

How do you get rid of keratosis Punctata?

Treatment options include topical keratolytics, emollients and occasionally systemic retinoids for severe cases. Systemic retinoids, such as etretinate, carry the risk of associated side effects such as hepatotoxicity.

Is Palmoplantar Keratoderma painful?

Pain is a prominent symptom in hereditary palmoplantar keratodermas (PPKs). Pain in patients with PPK can be difficult to treat. Pain mechanisms in PPKs are poorly understood.

How many people have PPK?

Punctate Palmoplantar Keratoderma (PPK) often appears in adolescence with epidermal thickening of the palms and soles characterized as hyperkeratotic growths. PPK occurs in 1 in 100,000 people and is acquired or inherited in an autosomal dominant inheritance pattern.

How many people have Pachyonychia congenita?

The number of patients worldwide who have pachyonychia congenita is estimated to be somewhere between 1,000 and 10,000 [1]. The International Pachyonychia Congenita Research Registry (IPCRR) reported 977 individuals with genetically confirmed pachyonychia congenita in January 2020 [1].

What is keratosis Punctata?

Keratosis punctata of the palmar creases is a common skin disorder that occurs most often in black patients, with skin lesions that are 1 to 5mm depressions filled with a comedo-like keratinous plug. Treatment with etretinate has been described.

What causes keratosis punctata of the palmar creases?

KPPC is associated with Dupuytren’s contracture and knuckle pads, but there is no association with malignancy. Biopsy reveals a hyperkeratotic plug depressing the epidermis. The differential diagnosis for palmar pits includes latent syphilis, arsenic exposure, verrucae vulgaris, and spiny keratoderma.

How do you get rid of Palmoplantar Keratoderma?

Treatment options may depend on the specific type of PPK a person has and may include:

Saltwater soaks.
Emollients.
Paring (cutting away layers of skin)
Topical keratolytics (useful for people with limited keratoderma)
Topical retinoids (this is often limited by skin irritation)
Systemic retinoids (acitretin)

Is Keratoderma curable?

Inherited palmoplantar keratodermas are not curable but symptoms can be controlled. The aim of treatment is to reduce the thickness of the skin and to soften the skin.

Is palmoplantar keratoderma curable?

How is palmoplantar keratoderma treated? Inherited palmoplantar keratodermas are not curable but symptoms can be controlled. The aim of treatment is to reduce the thickness of the skin and to soften the skin.

Is Pachyonychia congenita curable?

Like most genodermatoses, no specific treatment or cure is known for pachyonychia congenita. Therapy is generally directed towards symptomatically improving the most bothersome manifestations of the disease and, because of the rarity of pachyonychia congenita, is based largely on anecdotal findings.

What kind of skin condition is Palmoplantar keratodermas?

What is Palmoplantar keratodermas (PPK)? Palmoplantar keratodermas are a group of disorders characterized by thickening of the skin on the palms of the hands and soles of the feet of affected individuals.

What kind of skin is affected by Focal palmoplantar?

In focal palmoplantar keratoderma, usually only pressure or friction points are affected. In punctate palmoplantar keratoderma there are tiny skin spots on the palms and soles. Transgradient palmoplantar keratoderma is rare.

What is the name of the skin condition on the palms?

Also known a s keratosis palmaris et plantaris What is palmoplantar keratoderma? Palmoplantar keratoderma is the name given to a group of conditions where there is abnormal thickening of the skin on the palms of the hands and soles of the feet.

Can a child with palmoplantar keratoderma be deaf?

There is also an extremely rare genetic mutation that causes a combination of disorders known as palmoplantar keratoderma with deafness. Children affected by this condition develop hearing loss, particularly for high-pitched sounds, at around the same time the skin on their soles and palms begins to thicken.