What are DIO mice?

What are DIO mice?

A DIO (diet induced obese) mouse is a C57BL/6 – “Black 6” – mouse which has been made obese through conditioning with a special diet. These diets tend to be high in fat, however there are sometimes other modifications made such as added sugar and there are varying types of fat used to create the diet.

Why are C57BL 6J mice used?

C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice.

What does C57BL 6J stand for?

C57BL/6, often referred to as “C57 black 6”, “C57” or “black 6”, is a common inbred strain of laboratory mouse. It is the most widely used “genetic background” for genetically modified mice for use as models of human disease.

How much does a C57BL 6 cost?

Male Order code: 044 – US

What is DB db mice?

db/db Mice (JAX™ Mice Strain) Details db/db mice are used to model phase 1 to 3 of diabetes type II and obesity. Mice that are homozygous for the diabetes spontaneous mutation (Leprdb) demonstrate morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and come to be hypoinsulinemic.

How do mice induce obesity?

Obesity can be induced in mice by offering a high-fat diet. This is the most often used obesity model worldwide.

Why are BALB c mice used?

BALB/c mice are useful for research into both cancer and immunology. Most substrains have a “long reproductive life-span”, are noted for displaying high levels of anxiety and for being relatively resistant to diet-induced atherosclerosis, making them a useful model for cardiovascular research.

What is the difference between C57BL 6N and C57BL 6J?

C57BL/6J mice express a mutant Nnt gene, which is involved in glucose-mediated insulin secretion, compared to C57BL/6N substrains (Freeman et , 2006). C57BL/6N substrains harbor the retinal degeneration allele Crbrd8 while the C57BL/6J substrain carries a wildtype allele (Mattapallil et al., 2012).

What is the difference between C57BL 6 and C57BL 6J?

C57BL/6J is the parental substrain; “J” is the laboratory code for The Jackson Laboratory. Therefore, there is no source of “C57BL/6” mice; there is always a longer designation for each substrain indicating the institute or laboratory that maintains the different colonies.

What is the difference between C57BL 6 and BALB C?

BALB/c mice tend to produce a stronger humoral response than C57BL/6 mice. These strains have different gene sequences at the H2 site of the major histocompatibility (MHC)class I gene locus – BALB/c mice is H2d, while C57BL/6 is H2b. The difference in gene sequence of these two strains falls on the H2 locus.

Are C57BL 6 mice immunodeficient?

Also Known As:B6 scid, C57BL/6 scid These mice carry the severe combined immune deficiency mutation (scid, which is caused by a spontaneous mutation in the Prkdc gene) on the C57BL/6J strain background.

What kind of diet does a DIO mouse eat?

Diet Induced Obese (DIO) Mouse Models | C57BL/6NTac Male Mice | Taconic Biosciences Taconic Biosciences maintains an inventory of C57BL/6NTac male mice on 60% kcal high fat irradiated diet. Taconic uses Research Diets industry standard high fat rodent diet, D12492

Who is the director of the Jackson Laboratory?

Dr. James Keck, Senior Director, Innovation and Product Development, The Jackson Laboratory, presents De-risking Therapeutic Antibody Preclinical Drug Development: Simultaneous Assessment of Efficacy

When to put C57BL / 6J mice on diet?

DIO C57BL/6J mice are a model of pre-diabetic type 2 diabetes and obesity with mildly elevated blood glucose and impaired glucose tolerance for your metabolic studies. Study ready diet-induced obese (DIO) C57BL/6J males and controls are placed on diet at 6 weeks of age, and are available from 7-25 weeks of age to suit your unique research needs.

What kind of mice are KLB adipoko mice?

Klb AdipoKO mice were generated by crossing the βklotho gene floxed mice (Shanghai Nanfang Centre for Model Organisms) with adiponectin-Cre mice (The Jackson Laboratory, stock No. 010803). ..