What is KeratinoSens?

What is KeratinoSens?

The KeratinoSens is a reporter gene assay which uses an immortalised adherent cell line derived from an expanded clone of HaCaT human keratinocytes. This is established in parallel to cytotoxicity measurements to assess gene induction levels at sub-cytotoxic concentrations.

What is OECD method?

The OECD Guidelines for the testing of chemicals are a collection of the most relevant internationally agreed testing methods used by governments, industry and independent laboratories to assess the safety of chemicals.

ARE Nrf2 luciferase test method is used for?

The ARE-Nrf2 Luciferase Test is suitable for testing multi-constituent substances and mixtures and is more likely to predict low to moderate skin sensitization potential as opposed to high skin sensitization potential.

What is OECD Test for Schools?

The OECD Test for Schools, based on the OECD’s Programme for International Student Assessment (PISA), is a student assessment tool for schools and networks of schools that supports research, benchmarking and school-improvement efforts.

What is the role of OECD?

The main purpose of the OECD is to improve the global economy and promote world trade. It has been accomplished through the. It provides an outlet for the governments of different countries to work together to find solutions to common problems.

Which countries make up OECD?

OECD Member Countries

What is PISA based test for schools?

The PISA-based Test for Schools is a voluntary assessment intended to help school leaders from across the world understand their 15-year old students’ abilities to think critically and apply their knowledge creatively in novel contexts.

What is CCT PISA exam?

introduction Creative and Critical Thinking (CCT) exercise is a joyful and engaging activity aimed at enhancing the creative and critical thinking ability of students which help stimulate their minds and prepare them to proactively tackle the challenges of the 21st century.

What is the role of OECD in corporate governance?

‌The G20/OECD Principles of Corporate Governance help policy makers evaluate and improve the legal, regulatory, and institutional framework for corporate governance, with a view to supporting economic efficiency, sustainable growth and financial stability.

What is OECD and what is its brief mission statement?

The mission of the Organisation for Economic Co-operation and Development (OECD) is to promote policies that will improve the economic and social well-being of people around the world. The OECD provides a forum in which governments can work together to share experiences and seek solutions to common problems.

Which countries are not in OECD?

Non-OECD member countries: Argentina*, Brazil, India, Malaysia, Singapore, South Africa and Thailand are full adherents to MAD.

How is the keratinosens test used in the AOP?

Of the three human skin sensitisation tests that reflect Key Events in the Adverse Outcome Pathway (AOP), the KeratinoSens™ test represents Key Event 2, the activation of skin cells (keratinocytes) in the epidermis. Test items are classified based on a “two out of three” approach.

Why do you need to do a keratinosens test?

KERATINOSENS™ (OECD TEST GUIDELINE 442D) WHY CONDUCT A KERATINOSENS™ SKIN SENSITISATION TEST? Of the three human skin sensitisation tests that reflect Key Events in the Adverse Outcome Pathway (AOP), the KeratinoSens™ test represents Key Event 2, the activation of skin cells (keratinocytes) in the epidermis.

What does skin sensitisation mean in the OECD?

The present Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS).

What does EC 1.5 mean in keratinosens test?

* EC 1.5 represents the concentration for which gene induction is above the 1.5-fold threshold (i.e., 50% enhanced gene activity is obtained). The KeratinoSens™ data illustrated in Table 1 comprises of eight sensitizing compounds and five non-sensitizing compounds.