When should platelets be given in dengue?
When should platelets be given in dengue?
High-risk patients having platelet count < 20,000/cumm and risk of bleeding require urgent platelet transfusion. Patients with platelet count 21-40,000/cumm are in moderate risk and require platelet transfusion only if they have any haemorrhagic manifestations and other superadded conditions.
Why is platelet contraindicated in TTP?
Platelet transfusions are typically not recommended for patients with TTP because they have been hypothesized to provoke fatal thrombotic events.
Are platelets contraindicated in TTP?
Background: Platelet (PLT) transfusion has been considered contraindicated in patients with thrombotic thrombocytopenic purpura (TTP). However, adverse clinical outcomes and death in patients with TTP after receiving PLT transfusion were based on case reports prior to routine use of plasma exchange (PEX) therapy.
Why would a baby need a platelet transfusion?
Platelets: these are tiny cells in the blood that help prevent and stop bleeding. If your baby has a low platelet count and is bleeding, or at high risk of serious bleeding, he/she will be given a platelet transfusion.
What is the minimum platelet count for dengue?
A typical person has a platelet count of between 150,000 and 250,000 per microlitre of blood. About 80 to 90 per cent of patients with dengue will have levels below 100,000, while 10 to 20 per cent of patients will see critically low levels of 20,000 or less.
What is the safe platelet count in dengue?
The normal platelet count in human’s ranges from 1.5 to 4 lakh. In dengue, platelet count can drastically fall below 1.5 lakh….Why platelet count is important in dengue?
| Category | Platelet count (per cubic millimeter of blood) |
|---|---|
| Low risk | 40,000-100,000 |
| Moderate risk | 21-40,000 |
| High risk | < 20,000 |
Why platelet is not transfused in patients with ITP?
The therapeutic benefit of platelet transfusions in the management of ITP is controversial, as transfused platelets are short-lived, and platelet transfusion has been linked with increased risk of arterial thrombosis and mortality in platelet consumptive disorders such as thrombotic thrombocytopenic purpura and heparin …
How does TTP cause thrombocytopenia?
A lack of activity in the ADAMTS13 enzyme (a type of protein in the blood) causes thrombotic thrombocytopenic purpura (TTP). The ADAMTS13 gene controls the enzyme, which is involved in blood clotting. Not having enough enzyme activity causes overactive blood clotting.
Can platelet Transfusions be considered if the patient has autoimmune thrombocytopenia?
Therefore, current American Society of Hematology guidelines recommend that platelet transfusion in ITP patients be reserved for those with catastrophic hemorrhage or having concurrent surgery.
Can low platelets affect baby?
The baby is unlikely to develop low platelets if your decreased count is caused by regular dips in pregnancy or hypertension. However, if your low count is due to an immune condition, the antibodies that destroy platelets may cross the placenta and cause the same issues for the fetus.
Can a platelet transfusion be used for TTP?
Background: Platelet (PLT) transfusion has been considered contraindicated in patients with thrombotic thrombocytopenic purpura (TTP). However, adverse clinical outcomes and death in patients with TTP after receiving PLT transfusion were based on case reports prior to routine use of plasma exchange (PEX) therapy.
Can A Plt transfusion cause thrombotic complications?
PLT transfusions in patients with TTP do not appear harmful in regard to thrombotic complications. All deaths in the transfused group happened in very ill patients that had alternative causes of death. PLT transfusions in patients with TTP do not appear harmful in regard to thrombotic complications.
Is it safe to give PLT to TTP patients?
PLT transfusions in patients with TTP do not appear harmful in regard to thrombotic complications. All deaths in the transfused group happened in very ill patients that had alternative causes of death.
What are the adverse events of platelet transfusion?
An adverse event was defined as any complication including seizures, cerebrovascular accident, bleeding, thrombosis, myocardial infarction or death for any reason within 30 days from the PLT transfusion. Analyses were performed on only patients with ADAMTS13 activity <10%.