Why is Indocin used in pregnancy?

Indomethacin is an appropriate first-line tocolytic for the pregnant patient in early preterm labor (< 30 wk) or preterm labor associated with polyhydramnios. A more significant inflammatory response in the membranes and decidua is observed at gestational ages less than 30 weeks compared with 30-36 weeks.

Is indomethacin safe during pregnancy?

Women who are more than 32 weeks pregnant should avoid taking indomethacin, given the potential for heart problems in the baby. Women with a history of ulcers, bleeding disorders, or kidney or liver disease should also avoid taking indomethacin.

Can Indocid cause miscarriage?

When the researchers looked at women taking indomethacin alone, they found a 2.8 times higher risk of miscarriage. For those taking Cox-2 inhibitors, the risk rose by 43 percent, the study reported.

What does indomethacin do for preterm labor?

Indomethacin has been used for more than 25 years to stop preterm labor. It slows uterine contractions, delaying delivery. But it can cause serious side effects, including the constriction of a major blood vessel — the ductus arteriosus — in the fetus.

Why is indomethacin given?

Indomethacin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects …

Does indomethacin cross the placenta?

Indomethacin crosses the human placenta easily throughout gestation; only small amounts of the unchanged drug are found in the amniotic fluid.

What are the side effects of indomethacin 25 mg?

The most common side effects that occur with indomethacin include:

nausea.
vomiting.
heartburn.
diarrhea.
stomach pain.
constipation.
headache.
dizziness.

What painkillers can I take for miscarriage?

Take an over-the-counter pain medicine, such as acetaminophen (Tylenol) for cramps. Talk to your doctor before you take ibuprofen (Advil, Motrin) or naproxen (Aleve). Read and follow all instructions on the label. You may have cramps for several days after the miscarriage.

How long does it take indomethacin to stop contractions?

In the indomethacin group, 72.2% of women had inhibition of contractions for 7 days whereas 77.7% in the nifedipine group 90.2% of those in the combination group had a similar outcome (P = 0.021).

What is the role of prostaglandins in pregnancy?

When pregnant women go into labor, prostaglandins help cause the cervix to dilate and contractions to occur. Your doctor may use prostaglandins to induce labor if it’s decided that you should give birth before labor naturally occurs.

Can Indocin cause stomach problems?

Indocin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults. You should not use Indocin if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

How do I know if Im pregnant?

If you suspect you’re pregnant, the most definite way to find out, of course, is to take a pregnancy test. But there are signs and symptoms that can help clue you in, too. Here are some of them: Nausea. A queasy stomach is probably the most well-known early pregnancy symptom.

Can you take prednisone and Indocin together?

Using predniSONE together with indomethacin may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

Can Indocin cause bleeding?

Serious side effects of Indocin may include heart attack, stroke, skin changes (paleness, blisters, rash, and hives), weight gain, swelling, shortness of breath, tachycardia , unusual bleeding (including GI bleeding), jaundice, stomach pain, and pain with urination, bloody urine, blurry vision, and back pain.