Are CD1 mice outbred?

Are CD1 mice outbred?

CD-1 IGS mice are outbred mice derived from a group of outbred Swiss mice developed at the Anti-Cancer Center in Lausanne, Switzerland. They were imported to the US in 1926 and to Charles River in 1959. The CD-1 IGS mice are generally used for genetics, toxicology, pharmacology, and aging research.

Why use ICR mice?

ICR mice are one the most commonly available outbred population because they have good reproductive performance, are inexpensive, robust, and grow rapidly [5,6].

Is CD 1 a commonly used mouse strain?

Overview. CD1 IGS (also known as Crl:CD1(ICR)) is an albino outbred strain of mouse model that has frequently been used in toxicology and pharmacological research. It is the most popular strain of outbred mouse.

What is an IRC mice?

The ICR mouse is a strain of albino mice originating in SWISS and selected by Dr. Hauschka to create a fertile mouse line. Because mice of this strain have been sent to various places from the Institute of Cancer Research in the USA, the strain was named ICR after the initial letters of the institute.

Are CD1 mice aggressive?

Male CD1 mice are described as aggressive and territorial24,40, even when housed in sibling groups26. Additionally, it is known that nest building material can decrease inter-male aggression29, specifically when transferred during cage change6,28.

What are outbred mice?

Outbred mice are called stocks, which are defined as a closed population (for at least four generations) of genetically variable mice that are bred to maintain maximal heterozygosity. From: Laboratory Animal Medicine (Third Edition), 2015.

Why does Sprague have Dawley rats?

The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Its main advantage is its calmness and ease of handling.

What is albino mice?

The B6 albino strain is a spontaneous albino mutant coisogenic C57BL/6 strain. The mice contain a mutation in the tyrosinase gene, and when homozygous for the mutation the coat color of the mice is albino rather than black. To Charles River in 2009 from NCI.

Are CD 1 mice outbred?

CD-1, an outbred mouse line derived from the original colony of Swiss mice started in 1926 ( 9 ), are commonly used in toxicology and in chemical carcinogenicity bioassays.

Are BALB c mice immunodeficient?

BALB/c nude mice from University of Tartu, that lack a thymus and are unable to produce T-cells and are therefore immunodeficient.

Are male mice more aggressive than female mice?

Aggression and sexual behaviour are controlled by the same brain cells in male mice – but not in females. The finding suggests that males are more likely to become aggressive when they see a potential mate than females. Similar to humans, male mice are, on the whole, more aggressive than females.

How do you stop aggression in mice?

Transfer your mice to a new cage together if they are fighting.

1. Mice will often express aggression when being transferred to a cage that has some familiar smells, but isn’t exactly the same.
2. To counteract this, transfer the mice to an entirely new cage, with no objects from the old cage.

Where did the CD-1 IGS mouse come from?

CD-1® IGS Mouse | Charles River Laboratories. The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland.

Where did the HSD ICR mouse come from?

The Netherlands Israel Origin: The Hsd:ICR (CD-1®) mouse model is of Swiss origin and descended from the original two male and seven female albino non-inbred mice, imported by the Rockefeller Institute in 1926 from Lausanne, Switzerland.

What kind of research is done with C57BL / 6 mice?

The CD-1 IGS mice are generally used for genetics, toxicology, pharmacology, and aging research. C57BL/6 mice are inbred mice developed by C.C. Little in 1921 at The Bussey Institute for Research in Applied Biology.

What kind of mice are used for Transgenic Research?

C57BL/6 mice are inbred mice developed by C.C. Little in 1921 at The Bussey Institute for Research in Applied Biology. The C57BL/6 mice are used for transgenic and knockout model development (the wild-type C57BL/6 mice are a good control), as well as, obesity and immunological studies.