What are interferon inducible genes?
Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an Interferon stimulated gene (ISG), which is induced by type I, II, and III IFNs or after infection with a broad range of DNA and RNA viruses.
What does AIM2 stand for?
absent in melanoma 2
Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene. AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin.
What are interferon response genes?
An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. Interferons bind to receptors on the surface of a cell, initiating protein signaling pathways within the cell.
What do interferon-stimulated genes do?
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes. Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication.
What is AIM2 army?
Assignment Interactive Module 2.0 (AIM 2) is a web based information system designed to enhance the effectiveness and efficiency of the officer management process, and facilitate communication between Soldiers (e.g. officers & warrant officers with talents), Units (e.g. commanders with requirements) and the Officer …
Is AIM2 a PRR?
We now provide genetic evidence that AIM2 is a critical PRR uniquely involved in the recognition and innate immune defense against infection with the potentially lethal intracellular pathogen Francisella tularensis.
What do interferon stimulated genes do?
What is interferon immunity?
Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they “interfere” with viruses and keep them from multiplying.
What is interferon-stimulated response?
Type I IFNs cause the induction of a subset of genes termed IFN-stimulated genes (ISGs), which harbor a specific DNA element, IFN-stimulated response element (ISRE). This ISRE confers the responsiveness to the IFN signal through the binding of a family of transcription factors designated IFN regulatory factors (IRFs).
How do I find my army YMAV?
YMAV is now added to the Assignment Satisfaction Key (ASK) website. Under the Preferences/Volunteer tab on ASK, Soldiers will be able to view their YMAV. They should reach out to their Assignment Managers at HRC if they have any questions or concerns reference their YMAV.
What is a KSB army?
The Army defines talent as the unique intersection of knowledge, skills, behaviors, and preferences (KSB-Ps) in every officer.
What is the AIM2 inflammasome?
AIM2 is a cytosolic innate immune receptor which recognizes double-stranded DNA (dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of dsDNA leads to the assembly of a large multiprotein oligomeric complex termed the inflammasome.
Which receptors do Interferons bind to?
Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains.
Where does interferon come from?
An interferon is a protein produced by the body’s immune system in response to an infection. Interferons are part of a larger group of proteins known as cytokines , and they are made by cells such as leukocytes , T-cells, and fibroblasts . In addition to being made naturally in the body, interferon can also be produced in…
Who makes Interferon drug?
Two drug companies manufacture pegylated interferon. Roche Products Ltd make Pegasys ( interferon alpha 2A ) and MSD make PegIntron ( interferon alpha 2B ). They are similar, although not identical.
How are interferons produced?
Interferons are proteins produced by tumor cells or host cells that are infected with viruses, bacteria and other unknown nucleic acids .