What does HBV DNA detected mean?
The presence of HBV DNA in serum is a reliable marker of active HBV replication. HBV DNA levels are detectable by 30 days following infection, generally reach a peak at the time of acute hepatitis, and gradually decrease and disappear when the infection resolves spontaneously.
What is normal range of HBV DNA?
Normal range for this assay is Not Detected. The quantitative range of this assay is 1.00-9.00 log IU/mL (10-1,000,000,000 IU/mL). An interpretation of “Not Detected” does not rule out the presence of inhibitors in the patient specimen or HBV DNA concentration below the level of detection of the test.
Does HBV cause liver damage?
Chronic hepatitis B can develop into a serious disease resulting in long-term health problems, including liver damage, liver failure, liver cancer, and even death.
What are the stages of HBV?
It comprises the immune‐tolerant phase, immune‐active chronic phase, inactive HBsAg phase and reactivation. The four phases differ from each other in certain parameters such as serum ALT level, HBeAg status and viral load.
What does it mean if your hepatitis B surface antibody is positive?
(antibody to hepatitis B surface antigen): when this is “positive” or “reactive,” it means the person is immune to hepatitis B infec- tion, either from vaccination or from past infection.
How do you read hepatitis B blood test results?
A positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood. anti-HBs or HBsAb (Hepatitis B surface antibody) – A “positive” or “reactive” anti-HBs (or HBsAb) test result indicates that a person is protected against the hepatitis B virus.
What is HBV DNA qualitative test?
The HBV DNA test is performed on a blood sample using a Polymerase Chain Reaction (PCR) technique that rapidly generates HBV DNA fragments so they can be measured. Today, viral load is usually measured using international units per milliliter (IU/mL).
Can the liver repair itself from hepatitis B?
Reversing liver damage Liver Basics Barring complications, the liver can repair itself completely and, within a month, the patient will show no signs of damage. However, sometimes the liver gets overwhelmed and can’t repair itself completely, especially if it’s still under attack from a virus, drug, or alcohol.
How long does it take hepatitis B to damage the liver?
Seventy percent of carriers develop chronic persistent hepatitis B. Most do not appear to be ill. The remaining 30 percent of carriers experience continuous liver disease. This condition often progresses to cirrhosis and then, after 30 to 40 years, possibly to liver cancer.
Can a person with cirrhosis of the liver have HBV?
CONCLUSION: In conclusion, serum HBV DNA levels is strongly correlated with liver HBV DNA levels in chronic hepatitis B with cirrhosis. Liver free HBV DNA can still be detected in about half of the cirrhotic patients with undetectable serum HBV DNA.
When to consider a liver biopsy for HBV?
(3) Patients who remain HBeAg-positive with HBV DNA > 20 000 IU/mL after 3-6 mo with elevated ALT levels of 1-2 ULN, or DNA levels > 20 000 IU/mL and aged < 40 years old, should be considered for liver biopsy. Treatment should be considered if liver biopsy shows moderate/severe inflammation.
How does DNA guided hepatitis B treatment work?
The aim of the treatment in CHB patients is to achieve a maximum decrease in viral load. If serum DNA levels decrease to undetectable levels, by PCR, there is a reduction, not absence, of complications associated with HBV.
How are DNA levels related to liver disease?
It is known that maintained high levels of HBV DNA are associated with progressive liver disease. Serum DNA levels are a prognostic factor, and contribute to define the phase of CHB infection, the treatment indication, and allow an assessment of the efficacy of antiviral therapy.