What is a subclass immune deficiency?

What is a subclass immune deficiency?

People are said to have an IgG subclass deficiency when they lack or have very low levels of one or two IgG subclasses but have normal levels of other immunoglobulins.

What are symptoms of IgG deficiency?

What are the symptoms of an IgG deficiency?

  • Sinus infections and other respiratory infections.
  • Digestive tract infections.
  • Ear infections.
  • Pneumonia.
  • Bronchitis that keeps coming back, which can lead to permanent lung damage.
  • Infections that cause a sore throat.
  • Severe and life-threatening infections (rare)

What does it mean when IgG Subclass 2 is low?

IgG2 subclass deficiency is the most common subclass deficiency associated with recurrent infection. It may be accompanied by IgG4 deficiency, IgA deficiency, or both. Pure IgG subclass deficiency is rare in association with chronic lymphocytic leukemia.

What does IgG subclass 4 mean?

The diagnosis of autoimmune pancreatitis (AIP) and immunoglobulin subclass 4 (IgG4)-associated cholangitis (IAC) is based on imaging studies, serology, histology and a response to steroid therapy. The major serological finding is an elevation of the serum IgG4 concentration.

What autoimmune diseases cause low IgG?

Various autoimmune diseases are associated with IgA deficiency, including rheumatoid arthritis, systemic lupus erythematosus, Graves disease, type 1 diabetes, celiac disease, myasthenia gravis, pernicious anemia, and immune thrombocytopenic purpura.

How can I increase my IgG level?

7 easy ways to boost your immune system

  1. Eat lean protein at every meal.
  2. Shoot for 5 cups of fruits and veggies a day.
  3. Take a 10-minute walk a few times a day.
  4. Get your vitamin D levels checked.
  5. Reduce your stress levels.
  6. Cook with olive and canola oils.
  7. Limit your drinks.

How do you treat low IgG levels?

Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.

What is considered a low IgG level?

Usually the IgG level is less than 400 mg/dL; 70% of patients will have very low or absent IgA content. Documentation of impaired production of specific antibodies or poor response to vaccines is fundamental for this diagnosis. Peripheral B-cell numbers may be reduced or normal.

What does IgG deficiency mean?

IgG deficiency. IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy (THI), which may occur with or without additional decreases in IgA or IgM .

What is a low IgA level?

Normal, low, and deficient IgA levels. IgA levels between approximately 100 and 600 mg/dL 1 are considered to be normal. However, many individuals have IgA levels below 100 mg/dL but are not truly deficient. The double immunodiffusion assay may be used as a screening test to identify individuals with an IgA level below 2 to 4 mg/dL.

What does low IG mean?

Low IgG means something’s going on w/the immune system & is most often related to Primary Immune Deficiency Disorders. My son has the exact same thing- low IgA & low IgG but normal subsets (if those haven’t been tested, get them done b/c they give a better picture of what’s going on).

What causes low immunoglobulin?

Low levels of immunoglobulins mean your immune system isn’t working as well as it should. This can be caused by: Medicines that weaken your immune system, such as steroids. Diabetes complications. Kidney disease or kidney failure.